Voxel based morphometry reveals specific gray matter changes in primary dystonia
Identifieur interne : 002A98 ( Main/Exploration ); précédent : 002A97; suivant : 002A99Voxel based morphometry reveals specific gray matter changes in primary dystonia
Auteurs : Karl Egger [Autriche] ; Joerg Mueller [Autriche] ; Michael Schocke [Autriche] ; Christian Brenneis [Autriche] ; Martina Rinnerthaler [Autriche] ; Klaus Seppi [Autriche] ; Thomas Trieb [Autriche] ; Gregor K. Wenning [Autriche] ; Mark Hallett [États-Unis] ; Werner Poewe [Autriche]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-08-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Analysis of Variance, Brain (pathology), Brain Mapping, Dystonia, Dystonic Disorders (classification), Dystonic Disorders (pathology), Female, Humans, Magnetic Resonance Imaging (methods), Male, Middle Aged, Morphometry, Nervous system diseases, Nucleus accumbens, Orbitofrontal cortex, Voxel, globus pallidus internus, nucleus accumbens, orbitofrontal cortex, primary dystonia, voxel‐based morphometry.
- MESH :
- classification : Dystonic Disorders.
- methods : Magnetic Resonance Imaging.
- pathology : Brain, Dystonic Disorders.
- Adult, Analysis of Variance, Brain Mapping, Female, Humans, Male, Middle Aged.
Abstract
The present study assessed patterns of brain tissue alterations in different types of primary dystonia using voxel‐based morphometry (VBM). Nine patients with primary generalized dystonia (GD), 11 patients with primary cervical dystonia (CD), and 11 patients with primary focal hand dystonia (FHD) as well as 31 age and gender‐matched controls were included. When compared with healthy controls, patients with primary dystonia (n = 31) showed gray matter volume increase bilaterally in the globus pallidus internus, nucleus accumbens, prefrontal cortex, as well as unilaterally in the left inferior parietal lobe. This is the first study using VBM in patients with different types of primary dystonia, showing a common pattern of gray matter changes. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21619
Affiliations:
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Le document en format XML
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<term>Dystonic Disorders (classification)</term>
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<term>globus pallidus internus</term>
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<front><div type="abstract" xml:lang="en">The present study assessed patterns of brain tissue alterations in different types of primary dystonia using voxel‐based morphometry (VBM). Nine patients with primary generalized dystonia (GD), 11 patients with primary cervical dystonia (CD), and 11 patients with primary focal hand dystonia (FHD) as well as 31 age and gender‐matched controls were included. When compared with healthy controls, patients with primary dystonia (n = 31) showed gray matter volume increase bilaterally in the globus pallidus internus, nucleus accumbens, prefrontal cortex, as well as unilaterally in the left inferior parietal lobe. This is the first study using VBM in patients with different types of primary dystonia, showing a common pattern of gray matter changes. © 2007 Movement Disorder Society</div>
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